Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions.

ABSTRACT:

Background

The Arg-Gly-Asp (RGD) cell adhesion sequence occurs in several extracellular matrix molecules known to interact with integrin cell-surface receptors. Recently published crystal structures of the extracellular regions of two integrins in complex with peptides containing or mimicking the RGD sequence have identified the Arg and Asp residues as key specificity determinants for integrin recognition, through hydrogen bonding and metal coordination interactions. The central Gly residue also appears to be in close contact with the integrin surface in these structures.

Results

When hydrogen atoms are modelled on the central Gly residue with standard stereochemistry, the interaction between this residue and a carbonyl group in the integrin surface shows all the hallmarks o

SUBMITTER: Bella J 

PROVIDER: S-EPMC551611 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature