Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.

ABSTRACT:

Purpose

Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin-spin relaxation time constant ( T2*) that describes the decay of transverse magnetization. Use of the optimal TE during fMRI experiments allows maximal sensitivity to BOLD to be achieved. Reports that T2* values are longer in infants (due to higher water concentrations and lower lipid content) have led to the use of longer TEs during infant fMRI experiments; however, the optimal TE has not been established.

Methods

In this study, acute experimental mildly noxious stimuli were applied to the heel in 12 term infants (mean gestational age = 40 weeks, mean postnatal age = 3 days); and the percentage change in BOLD activity w

SUBMITTER: Goksan S 

PROVIDER: S-EPMC5516146 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature