Great interactions: How binding incorrect partners can teach us about protein recognition and function.

ABSTRACT: Protein-protein interactions play a key part in most biological processes and understanding their mechanism is a fundamental problem leading to numerous practical applications. The prediction of protein binding sites in particular is of paramount importance since proteins now represent a major class of therapeutic targets. Amongst others methods, docking simulations between two proteins known to interact can be a useful tool for the prediction of likely binding patches on a protein surface. From the analysis of the protein interfaces generated by a massive cross-docking experiment using the 168 proteins of the Docking Benchmark 2.0, where all possible protein pairs, and not only experimental ones, have been docked together, we show that it is also possible to predict a protein's binding re

SUBMITTER: Vamparys L 

PROVIDER: S-EPMC5516155 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature