Double oscillating diffusion encoding and sensitivity to microscopic anisotropy.

ABSTRACT:

Purpose

To introduce a novel diffusion pulse sequence, namely double oscillating diffusion encoding (DODE), and to investigate whether it adds sensitivity to microscopic diffusion anisotropy (µA) compared to the well-established double diffusion encoding (DDE) methodology.

Methods

We simulate measurements from DODE and DDE sequences for different types of microstructures exhibiting restricted diffusion. First, we compare the effect of varying pulse sequence parameters on the DODE and DDE signal. Then, we analyse the sensitivity of the two sequences to the microstructural parameters (pore diameter and length) which determine µA. Finally, we investigate specificity of measurements to particular substrate configurations.

Results

Simulations show that DODE sequences exhib

SUBMITTER: Ianus A 

PROVIDER: S-EPMC5516160 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature