Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

ABSTRACT: There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C₄, C₈, and C₁₈ (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible pol

SUBMITTER: Taresco V 

PROVIDER: S-EPMC5516180 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature