An <i>In Vitro</i> Chicken Gut Model Demonstrates Transfer of a Multidrug Resistance Plasmid from <i>Salmonella</i> to Commensal <i>Escherichia coli</i>.

ABSTRACT: The chicken gastrointestinal tract is richly populated by commensal bacteria that fulfill various beneficial roles for the host, including helping to resist colonization by pathogens. It can also facilitate the conjugative transfer of multidrug resistance (MDR) plasmids between commensal and pathogenic bacteria which is a significant public and animal health concern as it may affect our ability to treat bacterial infections. We used an in vitro chemostat system to approximate the chicken cecal microbiota, simulate colonization by an MDR Salmonella pathogen, and examine the dynamics of transfer of its MDR plasmid harboring several genes, including the extended-spectrum beta-lactamase bla_CTX-M1 We also evaluated the impact of cefotaxime administration on plasm

SUBMITTER: Card RM 

PROVIDER: S-EPMC5516254 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature