Von Willebrand factor deficiency reduces liver fibrosis in mice.

ABSTRACT: Liver diseases are associated with complex changes in the hemostatic system and elevated levels of the platelet-adhesive protein Von Willebrand factor (VWF) are reported in patients with acute and chronic liver damage. Although elevated levels of VWF are associated with fibrosis in the general population, the role of VWF in acute and chronic liver injury has not been examined in depth in experimental settings. We tested the hypothesis that VWF deficiency inhibits experimental liver injury and fibrosis. Wild-type (WT) and VWF-deficient mice were challenged with carbon tetrachloride (CCl₄) and the impact of VWF deficiency on acute liver injury and chronic liver fibrosis was determined. VWF deficiency did not significantly affect acute CCl₄-induced hepatocellular necrosi

SUBMITTER: Joshi N 

PROVIDER: S-EPMC5516268 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature