Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.

ABSTRACT: Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, and shortness of breath. Immune cells and airway structural cells orchestrate asthma pathophysiology, leading to mucus secretion, airway narrowing, and obstruction. Phosphoinositide 3-kinase, a lipid kinase, plays a crucial role in many of the cellular and molecular mechanisms driving asthma pathophysiology and represents an attractive therapeutic target. Here, we summarize the diverse roles of phosphoinositide 3-kinase in the pathogenesis of asthma and discuss novel therapeutic approaches to treatment.

SUBMITTER: Yoo EJ 

PROVIDER: S-EPMC5516292 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature