Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis.

ABSTRACT:

Background

Toxoplasma gondii, a common opportunistic protozoan, is a leading cause of illness and mortality among immunosuppressed individuals and during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effective at curtailing disease progression in these cases. Given the parasite ability to influence host immunity and metabolism, understanding of the metabolic alterations in the host's immune organs during T. gondii infection may enhance the understanding of the molecular mechanisms that define the pathophysiology of T. gondii infection.

Methods

We investigated the global metabolic changes in the spleen of BALB/c mice at early and late stage of infection with T. gondii using LC-MS/MS-based metabolomics. Multivariate data analysis methods

SUBMITTER: Chen XQ 

PROVIDER: S-EPMC5516376 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature