Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study.

ABSTRACT:

Background

Exposure to arsenic in drinking water is a global health problem and arsenic-induced skin lesions are hallmark of chronic arsenic toxicity. We and others have reported germline genetic variations as risk factors for such skin lesions. The role of copy number variation (CNV) in the germline DNA in this regard is unknown.

Methods

From a large prospectively followed-up cohort, exposed to arsenic, we randomly selected 2171 subjects without arsenic-induced skin lesions at enrollment and genotyped their whole blood DNA samples on Illumina Cyto12v2.1 SNP chips to generate DNA copy number. Participants were followed up every 2 years for a total of 8 years, especially for the development of skin lesions. In Cox regression models, each CNV segment was used as a predictor, a

SUBMITTER: Kibriya MG 

PROVIDER: S-EPMC5516382 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature