Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria.

ABSTRACT:

Introduction

In phenylketonuria (PKU), a natural protein-restricted dietary treatment prevents severe cognitive impairment. Nutrient deficiencies may occur due to strict diet. This study is aimed at evaluating the dietary intake and blood concentrations of micronutrients and essential fatty acids (FA), bone mineral density (BMD) and fracture history in patients on long-term dietary treatment.

Methods

Sixty early diagnosed Dutch patients (aged 1-39 years) were included in a multi-center cross-sectional study. Their dietary intake, blood concentrations of micronutrients, FA, fracture history and BMD were assessed.

Results

Selenium dietary intake and serum concentrations were low in 14 and 46% of patients, respectively. The serum 25-OH vitamin D2 + D3 concentration was l

SUBMITTER: Demirdas S 

PROVIDER: S-EPMC5516403 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature