Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample.

ABSTRACT:

Background

Periodontal disease (PD) is a multifactorial illness in which environment and host interact. The genetic component plays a key role in the onset of PD. In fact the genetic compound can modulate the inflammation of the mucous membranes and the loss of alveolar bone. The genetics of PD is not well understood. Previous studies suggest a strong association between PD occurrence and individual genetic profile. The role of genetic susceptibility could impact on the clinical manifestations of PD, and consequently on prevention and therapy.

Materials and methods

Genetic polymorphisms of VRD, IL6 and IL10 were investigated in Italian adults affected by PD. 571 cases classified according the criteria of the American Academy of Periodontology were included. All patients were

SUBMITTER: Tettamanti L 

PROVIDER: S-EPMC5516423 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature