Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson's disease: a task-based fMRI study.

ABSTRACT:

Background

The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes.

Aims

To delineate the functional patterns of brain network activity and connectivity underlying visual hallucinations in Parkinson's disease.

Methods

In this study, we combined functional magnetic resonance imaging (MRI) with a behavioral task capable of eliciting visual misperceptions, a confirmed surrogate for visual hallucinations, in 35 patients with idiopathic Parkinson's disease. We then applied an independent component analysis to extract time series information for large-scale neuronal networks that have been previously implicated in the pathophysiology of visual hallucinat

SUBMITTER: Shine JM 

PROVIDER: S-EPMC5516559 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature