δ Subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice.
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ABSTRACT:
SUBMITTER: Zhang WH
PROVIDER: S-EPMC5516689 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
δ Subunit-containing GABA<sub>A</sub> receptor prevents overgeneralization of fear in adult mice.
Zhang Wen-Hua WH Zhou Jin J Pan Han-Qing HQ Wang Xiao-Yang XY Liu Wei-Zhu WZ Zhang Jun-Yu JY Yin Xiao-Ping XP Pan Bing-Xing BX
Learning & memory (Cold Spring Harbor, N.Y.) 20170717 8
The role of δ subunit-containing GABA<sub>A</sub> receptor (GABA<sub>A</sub>(δ)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion of GABA<sub>A</sub>(δ)R and using protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, we observed that when the two tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more ...[more]
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