Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis.

ABSTRACT:

Objective

Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis-post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease. The objective is to quantitatively describe the loss of cell viability and function in cartilage after an injurious impact and identify the key parameters and variables that contribute to this phenomenon.

Methods

We constructed a sys

SUBMITTER: Kapitanov GI 

PROVIDER: S-EPMC5516774 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature