Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes.

ABSTRACT: Exosomes are membrane-enclosed extracellular vesicles derived from cells, carrying biomolecules that include proteins and nucleic acids for intercellular communication. Owning to their advantages of size, structure, stability, and biocompatibility, exosomes have been used widely as natural nanocarriers for intracellular delivery of theranostic agents. Meanwhile, surface modifications needed to endow exosomes with additional functionalities remain challenging by their small size and the complexity of their membrane surfaces. Current methods have used genetic engineering and chemical conjugation, but these strategies require complex manipulations and have only limited applications. Herein, we present an aptamer-based DNA nanoassemblies on exosome surfaces. This in situ assembly method is bas

SUBMITTER: Wan S 

PROVIDER: S-EPMC5516796 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature