Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways.

ABSTRACT: Cellular stress responses require exquisite coordination between intracellular signaling molecules to integrate multiple stimuli and actuate specific cellular behaviors. Deciphering the web of complex interactions underlying stress responses is a key challenge in understanding robust biological systems and has the potential to lead to the discovery of targeted therapeutics for diseases triggered by dysregulation of stress response pathways. We constructed large-scale molecular interaction maps of six major stress response pathways in Saccharomyces cerevisiae (baker's or budding yeast). Biological findings from over 900 publications were converted into standardized graphical formats and integrated into a common framework. The maps are posted at http://www.yeast-maps.org/yeast-stress-

SUBMITTER: Kawakami E 

PROVIDER: S-EPMC5516916 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature