Proteomics analyses of prostate cancer cells reveal cellular pathways associated with androgen resistance.

ABSTRACT: While significant advances have been made in the diagnosis and treatment of prostate cancer, each year tens of thousands of men still die from prostate cancer in the United States. Thus, greater understanding of cellular pathways and molecular basis of prostate cancer progression in the development of androgen resistance is needed to treat these lethal phenotypes. To dissect the mechanism of androgen resistance, we utilize a proteomics approach to study the development of androgen resistance in LNCaP prostate cancer cells. Our results showed the predominant involvement of metabolic pathways that were elevated in androgen resistance phenotype. We further found the amplification of PI3K/AKT pathway and the overexpression of proteasome proteins while the mitochondrial oxidation phosphorylatio

SUBMITTER: Hoti N 

PROVIDER: S-EPMC5516940 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature