Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell JP
PROVIDER: S-EPMC5516944 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20170609 7
The endoplasmic reticulum (ER) forms a branched, dynamic membrane tubule network that is vital for cellular function. Branching arises from membrane fusion facilitated by the GTPase atlastin (ATL). Many metazoan genomes encode for three ATL isoforms that appear to fulfill partially redundant function despite differences in their intrinsic GTPase activity and localization within the ER; however, the underlying mechanistic differences between the isoforms are poorly understood. Here, we identify d ...[more]