Postnatal dexamethasone, respiratory and neurodevelopmental outcomes at two years in babies born extremely preterm.

ABSTRACT:

Importance

Postnatal dexamethasone is associated with reduction in bronchopulmonary dysplasia. There remains, however, concern that its short-term benefits are accompanied by long-term adverse effects e.g. poorer neurodevelopmental outcomes.

Objective

Our aim was to determine the effects of administration of postnatal dexamethasone on respiratory and neurodevelopmental outcome at two years of age after adjusting for neonatal and infant risk factors.

Materials and methods

The study included 412 infants born at 23-28 weeks of gestation, 29% had received postnatal dexamethasone. Two outcomes were examined, respiratory hospital admissions in the past 12 months and neurodevelopmental impairment. Logistic regression, adjusted for sex, birthweight z-score, gestation, materna

SUBMITTER: Qin G 

PROVIDER: S-EPMC5517008 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature