The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies.

ABSTRACT: It is of substantial interest to study the effects of genes, genetic pathways, and networks on the risk of complex diseases. These genetic constructs each contain multiple SNPs, which are often correlated and function jointly, and might be large in number. However, only a sparse subset of SNPs in a genetic construct is generally associated with the disease of interest. In this article, we propose the generalized higher criticism (GHC) to test for the association between an SNP set and a disease outcome. The higher criticism is a test traditionally used in high-dimensional signal detection settings when marginal test statistics are independent and the number of parameters is very large. However, these assumptions do not always hold in genetic association studies, due to linkage disequilibri

SUBMITTER: Barnett I 

PROVIDER: S-EPMC5517103 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature