CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.

ABSTRACT:

Background

Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p450 3A (CYP3A) family as candidate MeHg susceptibility genes.

Objectives

We evaluated whether genetic variation in CYP3A genes influences the association between prenatal exposure to MeHg and child neuropsychological development.

Methods

The study population included 2639 children from three birth cohort studies: two subcohorts in Seychelles (SCDS) (n=1160, 20 and 30months of age, studied during the years 2001-2012), two subcohorts from Spain (INMA) (n=625, 14months

SUBMITTER: Llop S 

PROVIDER: S-EPMC5517297 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature