Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation.

ABSTRACT:

Background

Standard repetitive transcranial magnetic stimulation (rTMS) devices generate bidirectional biphasic sinusoidal pulses that are energy efficient, but may be less effective than monophasic pulses that induce a more unidirectional electric field. To enable pulse shape optimization, we developed a controllable pulse parameter TMS (cTMS) device.

Objective

We quantified changes in cortical excitability produced by conventional sinusoidal bidirectional pulses and by three rectangular-shaped cTMS pulses, one bidirectional and two unidirectional (in opposite directions), and compared their efficacy in modulating motor evoked potentials (MEPs) produced by stimulation of motor cortex.

Methods

Thirteen healthy subjects completed four sessions of 1 Hz rTMS of the left

SUBMITTER: Goetz SM 

PROVIDER: S-EPMC5517314 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature