A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.

ABSTRACT:

Background

The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection.

Methods

Within the European comprehensive treatment strategy for childhood LGG, the International Society of Paediatric Oncology-Low Grade Glioma (SIOP LGG) Committee launched a randomised trial involving 118 institutions and 11 countries to investigate the addition of etoposide (100 mg/m², days 1, 2 & 3) to a four-course induction of vincristine (1.5 mg/m² × 10 wkly) and carboplatin (550 mg/m² q 3 weekly) as part of 18-month continuing treatment programme. Patients were recruited after imaging diagnosis,

SUBMITTER: Gnekow AK 

PROVIDER: S-EPMC5517338 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature