Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2_A Receptor to Promote the Establishment of Infection.

ABSTRACT: Adenosine is an endogenously released purine nucleoside that signals through four widely expressed G protein-coupled receptors: A1, A2_A, A2_B, and A3. Of these, A_2AR is recognized as mediating major adenosine anti-inflammatory activity. During cutaneous leishmaniasis, adenosine induces immunosuppression, which promotes the establishment of infection. Herein, we demonstrated that A_2AR signaling is exploited by Leishmania infantum parasites, the etiologic agent that causes Visceral Leishmaniasis, to successfully colonize the vertebrate host. A_2AR gene-deleted mice exhibited a well-developed cellular reaction with a strong Th1 immune response in the parasitized organs. An intense infiltration of activated neutrophils into the diseas

SUBMITTER: Lima MHF 

PROVIDER: S-EPMC5517451 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature