CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

ABSTRACT: Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 ^Tg /Cd300f ^-/- mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 ^Tg /Cd300f ^-/- mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f ^-/- mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which

SUBMITTER: Rozenberg P 

PROVIDER: S-EPMC5517555 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature