A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.

ABSTRACT: The human placenta plays a crucial role as the interface between mother and fetus. It represents a unique tissue that undergoes morphological as well as functional changes on the cellular and tissue level throughout pregnancy. To better understand how the placenta works, a variety of techniques has been developed to re-create this complex physiological barrier in vitro. However, due to the low availability of freshly isolated primary cells, choriocarcinoma cell lines remain the usual suspects as in vitro models for placental research. Here, we present a comparative study on the functional aspects of the choriocarcinoma cell lines BeWo, JAR and Jeg-3, as well as the first trimester trophoblast cell line ACH-3P as placental in vitro barrier models for endocrine and transport studies. Functio

SUBMITTER: Rothbauer M 

PROVIDER: S-EPMC5517571 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature