High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona.

ABSTRACT: The recent epidemic of Ebola virus disease in West Africa resulted in an unprecedented number of cases and deaths. Due to the scope of the outbreak combined with the lack of available approved treatment options, there was strong motivation to investigate any potential drug which had existing data reporting anti-Ebola activity. Drugs with demonstrated antiviral activity in the nonhuman primate models already approved for another indication or for which there was existing safety data were considered to be priorities for evaluation by the World Health Organization. Sertraline hydrochloride was reported to have anti-Ebola activity in vitro alone and in combination with other approved drugs. Although the efficacy was less than 100% in the murine model, the established safety profile of this pro

SUBMITTER: Honko AN 

PROVIDER: S-EPMC5517626 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature