Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis.

ABSTRACT: The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl₄)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl₄ rendered significant increases in serum alanine aminotransferase and aspartate aminotransferase, hepatic malondialdehyde formation, decreases in antioxidants including superoxide dismutase and glutathione, and up-regulated expressions of transforming growth factor-β1, α-smooth muscle actin, tumor necrosis factor-α and interleukin-1β in the liver tissues. Hydroxyproline contents in the rat livers were increased by CCl₄. Histopathological examinations indicated that CCl₄ induced extensive necrosis in mice livers and pseudo-lobule formations,

SUBMITTER: Li X 

PROVIDER: S-EPMC5517632 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature