Ontology highlight
ABSTRACT:
SUBMITTER: AlShamaileh H
PROVIDER: S-EPMC5517644 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170719 1
The development of chemoresistance and inability in elimination of cancer stem cells are among the key limitations of cancer chemotherapy. Novel molecular therapeutic strategies able to overcome such limitations are urgently needed for future effective management of cancer. In this report, we show that EpCAM-aptamer-guided survivin RNAi effectively downregulated survivin both in colorectal cancer cells in vitro and in a mouse xenograft model for colorectal cancer. When combined with the conventi ...[more]