Generally Applicable Transformation Protocols for Fluorescent Nanodiamond Internalization into Cells.

ABSTRACT: Fluorescent nanodiamonds (FNDs) are promising nanoprobes, owing to their stable and magnetosensitive fluorescence. Therefore they can probe properties as magnetic resonances, pressure, temperature or strain. The unprecedented sensitivity of diamond defects can detect the faint magnetic resonance of a single electron or even a few nuclear spins. However, these sensitivities are only achieved if the diamond probe is close to the molecules that need to be detected. In order to utilize its full potential for biological applications, the diamond particle has to enter the cell. Some model systems, like HeLa cells, readily ingest particles. However, most cells do not show this behavior. In this article we show for the first time generally applicable methods, which are able to transport fluorescen

SUBMITTER: Hemelaar SR 

PROVIDER: S-EPMC5517665 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature