Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors.

ABSTRACT:

Background

The recent reduction in mortality due to malaria is being threatened by the appearance of Plasmodium falciparum parasites that are resistant to artemisinin in Southeast Asia. To limit the impact of resistant parasites and their spread across the world, there is a need to validate anti-malarial drug targets and identify new leads that will serve as foundations for future drug development programmes targeting malaria. Towards that end, the antiplasmodial potential of several Hsp90 inhibitors was characterized. Because, the Hsp90 chaperone has been suggested as a good drug target against multiple parasitic infections including malaria.

Results

Chemically diverse sets of Hsp90 inhibitors, evaluated in clinical trials as anti-cancer agents, were tested against the mala

SUBMITTER: Murillo-Solano C 

PROVIDER: S-EPMC5518105 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature