Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter.

ABSTRACT:

Background

Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction. To investigate the protective effect of CA against UPM-mediated collapse of the pulmonary alveolar epithelial (PAE) cell (NCI-H441), barrier integrity parameters, and their elements were evaluated in PAE.

Methods

CA was acquired from the laboratory previous reports. UPM was obtained from the National Institutes of Standards and Technology, and these were collected in St. Louis, MO, over a 24-month period and used as a standard reference. To confirm the protection of PAE barrier integrity, paracellular permeability and the juncti

SUBMITTER: Lee KW 

PROVIDER: S-EPMC5518117 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature