Coadministration of lorcaserin and phentermine for weight management: A 12-week, randomized, pilot safety study.

ABSTRACT:

Objective

To assess the short-term tolerability of lorcaserin alone or with two dose regimens of phentermine.

Methods

This was a 12-week, randomized, double-blind, pilot safety study of N = 238 nondiabetic patients with obesity or overweight with ≥1 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting ≥ 1 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and ≥5% WL are reported.

Results

N = 238 were randomized, and N = 235 were treated. N = 94 reported potentially serotonergic AEs: 37.2% LOR BID, 42.3% LOR BID+PHEN QD, and 40.5% LOR BID+PHEN BID. AEs leading to discontinuation were reported approximately

SUBMITTER: Smith SR 

PROVIDER: S-EPMC5518190 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature