Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors.

ABSTRACT: Modulation of gamma oscillations is important for the processing of information and the disruption of gamma oscillations is a prominent feature of schizophrenia and Alzheimer's disease. Gamma oscillations are generated by the interaction of excitatory and inhibitory neurons where their precise frequency and amplitude are controlled by the balance of excitation and inhibition. Acetylcholine enhances the intrinsic excitability of pyramidal neurons and suppresses both excitatory and inhibitory synaptic transmission, but the net modulatory effect on gamma oscillations is not known. Here, we find that the power, but not frequency, of optogenetically induced gamma oscillations in the CA3 region of mouse hippocampal slices is enhanced by low concentrations of the broad-spectrum cholinergic agonis

SUBMITTER: Betterton RT 

PROVIDER: S-EPMC5518221 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature