Contributions of imprecision in PET-MRI rigid registration to imprecision in amyloid PET SUVR measurements.

ABSTRACT: Quantitative measurement of β-amyloid from amyloid PET scans typically relies on localizing target and reference regions by image registration to MRI. In this work, we present a series of simulations where 50 small random perturbations of starting location and orientation were applied to each subject's PET scan, and rigid registration using spm_coreg was performed between each perturbed PET scan and its corresponding MRI. We then measured variation in the output PET-MRI registrations and how this variation affected the resulting SUVR measurements. We performed these experiments using scans of 1196 participants, half using 18F florbetapir and half using 11C PiB. From these experiments, we measured the magnitude of the imprecision in the rigid registration steps used to localize measurement

SUBMITTER: Schwarz CG 

PROVIDER: S-EPMC5518286 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature