Weight History and All-Cause and Cause-Specific Mortality in Three Prospective Cohort Studies.

ABSTRACT:

Background

The relationship between body mass index (BMI) and mortality is controversial.

Objective

To investigate the relationship between maximum BMI over 16 years and subsequent mortality.

Design

3 prospective cohort studies.

Setting

Nurses' Health Study I and II and Health Professionals Follow-Up Study.

Participants

225 072 men and women with 32 571 deaths observed over a mean of 12.3 years of follow-up.

Measurements

Maximum BMI over 16 years of weight history and all-cause and cause-specific mortality.

Results

Maximum BMIs in the overweight (25.0 to 29.9 kg/m2) (multivariate hazard ratio [HR], 1.06 [95% CI, 1.03 to 1.08]), obese I (30.0 to 34.9 kg/m2) (HR, 1.24 [CI, 1.20 to 1.29]), and obese II (≥35.0 kg/m2) (HR, 1.73 [CI, 1.66 to 1.80

SUBMITTER: Yu E 

PROVIDER: S-EPMC5518318 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature