Regional susceptibility to dose-dependent white matter damage after brain radiotherapy.

ABSTRACT:

Background and purpose

Regional differences in sensitivity to white matter damage after brain radiotherapy (RT) are not well-described. We characterized the spatial heterogeneity of dose-response across white matter tracts using diffusion tensor imaging (DTI).

Materials and methods

Forty-nine patients with primary brain tumors underwent MRI with DTI before and 9-12months after partial-brain RT. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were generated. Atlas-based white matter tracts were identified. A secondary analysis using skeletonized tracts was also performed. Linear mixed-model analysis of the relationship between mean and max dose and percent change in DTI metrics was performed.

Results

Tracts

SUBMITTER: Connor M 

PROVIDER: S-EPMC5518466 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature