ALX receptor ligands define a biochemical endotype for severe asthma.

ABSTRACT:

Background

In health, inflammation resolution is an active process governed by specialized proresolving mediators and receptors. ALX/FPR2 receptors (ALX) are targeted by both proresolving and proinflammatory ligands for opposing signaling events, suggesting pivotal roles for ALX in the fate of inflammatory responses. Here, we determined if ALX expression and ligands were linked to severe asthma (SA).

Methods

ALX expression and levels of proresolving ligands (lipoxin A4 [LXA4], 15-epi-LXA4, and annexin A1 [ANXA1]), and a proinflammatory ligand (serum amyloid A [SAA]) were measured in bronchoscopy samples collected in Severe Asthma Research Program-3 (SA [n = 69], non-SA [NSA, n = 51] or healthy donors [HDs, n = 47]).

Results

Bronchoalveolar lavage (BAL) fluid LXA4 and

SUBMITTER: Ricklefs I 

PROVIDER: S-EPMC5518567 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature