Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.

ABSTRACT:

Rationale

Mutations in ACTA2, encoding the smooth muscle isoform of α-actin, cause thoracic aortic aneurysms, acute aortic dissections, and occlusive vascular diseases.

Objective

We sought to identify the mechanism by which loss of smooth muscle α-actin causes aortic disease.

Methods and results

Acta2^-/- mice have an increased number of elastic lamellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography that can be attenuated by treatment with losartan, an angiotensin II (AngII) type 1 receptor blocker. AngII levels are not increased in Acta2^-/- aortas or kidneys. Aortic tissue and explanted smooth muscle cells from Acta2^-/- aortas show increased production of reactiv

SUBMITTER: Chen J 

PROVIDER: S-EPMC5518614 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature