Effect of lipid peroxidation on membrane permeability of cancer and normal cells subjected to oxidative stress.

ABSTRACT: We performed molecular dynamics simulations to investigate the effect of lipid peroxidation products on the structural and dynamic properties of the cell membrane. Our simulations predict that the lipid order in a phospholipid bilayer, as a model system for the cell membrane, decreases upon addition of lipid peroxidation products. Eventually, when all phospholipids are oxidized, pore formation can occur. This will allow reactive species, such as reactive oxygen and nitrogen species (RONS), to enter the cell and cause oxidative damage to intracellular macromolecules, such as DNA or proteins. On the other hand, upon increasing the cholesterol fraction of lipid bilayers, the cell membrane order increases, eventually reaching a certain threshold, from which cholesterol is able to protect the m

SUBMITTER: Van der Paal J 

PROVIDER: S-EPMC5518669 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature