Identification of four prognostic LncRNAs for survival prediction of patients with hepatocellular carcinoma.

ABSTRACT:

Background

As the fifth most common cancer worldwide, Hepatocellular carcinoma (HCC) is also the third most common cause of cancer-related death in China. Several lncRNAs have been demonstrated to be associated with occurrence and prognosis of HCC. However, identification of prognostic lncRNA signature for HCC with expression profiling data has not been conducted yet.

Methods

With the reuse of public available TCGA data, expression profiles of lncRNA for 371 patients with HCC were obtained and analyzed to find the independent prognostic lncRNA. Based on the expression of lncRNA, we developed a risk score model, which was evaluated by survival analysis and ROC (receiver operating characteristic) curve. Enrichment analysis was performed to predict the possible role of the iden

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5518732 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature