Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.

ABSTRACT:

Objective

In response to a need for better sepsis diagnostics, several new gene expression classifiers have been recently published, including the 11-gene "Sepsis MetaScore," the "FAIM3-to-PLAC8" ratio, and the Septicyte Lab. We performed a systematic search for publicly available gene expression data in sepsis and tested each gene expression classifier in all included datasets. We also created a public repository of sepsis gene expression data to encourage their future reuse.

Data sources

We searched National Institutes of Health Gene Expression Omnibus and EBI ArrayExpress for human gene expression microarray datasets. We also included the Glue Grant trauma gene expression cohorts.

Study selection

We selected clinical, time-matched, whole blood studies of sepsis and

SUBMITTER: Sweeney TE 

PROVIDER: S-EPMC5518756 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature