The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting.

ABSTRACT:

Objective

Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Adequate examination of the identity, function, and relevance of specific subsets of GHSR-expressing neurons has been hampered by the absence of a suitable Cre recombinase (Cre)-expressing mouse line with which to manipulate gene expression in a targeted fashion within GHSR-expressing neurons. The present study aims to characterize the functional significance and neurocircuitry of GHSR-expressing neurons in the mediobasal hypothalamus (MBH), as they relate to ghrelin-induced food intake and fasting-associated rebound hyperphagi

SUBMITTER: Mani BK 

PROVIDER: S-EPMC5518774 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature