Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study.

ABSTRACT:

Background

Statin use after colorectal cancer diagnosis may improve survival but evidence from observational studies is conflicting. The anti-cancer effect of statins may be restricted to certain molecular subgroups. In this population-based cohort study, the interaction between p53 and 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGCR) expression, KRAS mutations, and the association between statin use and colon cancer survival was assessed.

Methods

The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008. Statin use was determined through clinical note review. Tissue blocks were retrieved to determine immunohistochemical expression of p53 and HMGCR in tissue microarrays and the presence of KRAS mutations in extracted DNA. Cox p

SUBMITTER: Gray RT 

PROVIDER: S-EPMC5518863 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature