Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders.

ABSTRACT:

Introduction

Sigma-1 receptors (Sig-1Rs) are molecular chaperones that reside mainly in the endoplasmic reticulum (ER) but exist also in the proximity of the plasma membrane. Sig-1Rs are highly expressed in the CNS and are involved in many cellular processes including cell differentiation, neuritogenesis, microglia activation, protein quality control, calcium-mediated ER stress and ion channel modulation. Disturbance in any of the above cellular processes can accelerate the progression of many neurological disorders; therefore, the Sig-1R has been implicated in several neurological diseases.

Areas covered

This review broadly covers the functions of Sig-1Rs including several neurodegenerative disorders in humans and drug addiction-associated neurological disturbance in the ca

SUBMITTER: Tsai SY 

PROVIDER: S-EPMC5518923 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature