Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure.

ABSTRACT: The hypothesis that developmental estrogenic exposure induces a constellation of male reproductive tract abnormalities is supported by experimental and human evidence. Experimental data also suggest that some induced effects persist in descendants of exposed males. These multi- and transgenerational effects are assumed to result from epigenetic changes to the germline, but few studies have directly analyzed germ cells. Typically, studies of transgenerational effects have involved exposing one generation and monitoring effects in subsequent unexposed generations. This approach, however, has limited human relevance, since both the number and volume of estrogenic contaminants has increased steadily over time, intensifying rather than reducing or eliminating exposure. Using an outbred CD-1 mou

SUBMITTER: Horan TS 

PROVIDER: S-EPMC5519010 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature