Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity.

ABSTRACT: Long-term spaceflight affects numerous organ systems in the body, including metabolic dysfunction. Recently, ample evidence has demonstrated that the liver is a vulnerable organ during spaceflight. However, the changes in hepatocyte proliferation and cell cycle control under microgravity remain largely unexplored. In the present study, we first confirmed that the serum levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, biochemical markers of liver function, were altered in rats under tail suspension (TS) conditions to simulate microgravity, as shown in previous reports. Next, we demonstrated that the cell proliferation activity, determined by Ki67, PCNA and PH3, was significantly decreased at the different TS time points (TS for 14, 28 and 42 days) com

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5519018 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature