Effect of therapy switch on time to second-line antiretroviral treatment failure in HIV-infected patients.

ABSTRACT:

Background

Switch from first line antiretroviral therapy (ART) to second-line ART is common in clinical practice. However, there is limited knowledge of to which extent different reason for therapy switch are associated with differences in long-term consequences and sustainability of the second line ART.

Material and methods

Data from 869 patients with 14601 clinical visits between 1999-2014 were derived from the national cohort database. Reason for therapy switch and viral load (VL) levels at first-line ART failure were compared with regard to outcome of second line ART. Using the Laplace regression model we analyzed the median, 10th, 20th, 30th and 40th percentile of time to viral failure (VF).

Results

Most patients (n = 495; 57.0%) switched from first-line to secon

SUBMITTER: Haggblom A 

PROVIDER: S-EPMC5519043 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature