Ontology highlight
ABSTRACT:
SUBMITTER: Venteicher AS
PROVIDER: S-EPMC5519096 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170301 6332
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between IDH-mutant astrocytoma and oligodendroglioma can be primarily explained by distinct TME and ...[more]